Kosin Medical Journal

Risk factors for central and lateral lymph node metastasis in papillary thyroid carcinoma: Ji Hyun Ahn, Hee Kyung Chang; Kosin Med J. 2022;37(4):311-319. Published online December 19, 2022; DOI: https://doi.org/10.7180/kmj.22.136

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Background
Lymph node metastasis (LNM) is commonly observed in papillary thyroid carcinoma. This study aimed to investigate the risk factors for LNM in patients with papillary thyroid carcinoma.
Methods
The clinicopathological factors of 417 patients were investigated, and differences according to the presence or absence of LNM were evaluated.
Results
LNM was associated with age <55 years, male sex, tumor size >10 mm, multiple and bilateral tumors, tumor involving the lower pole or entire lobe, lymphovascular invasion (LVI), perineural invasion (PNI), and extrathyroidal extension (ETE). Univariable and multivariable analyses showed that age <55 years, male sex, tumor size >10 mm, LVI, and ETE were related to central LNM. Male sex, tumor size >10 mm, and LVI were correlated with lateral LNM (p<0.05). Compared to central LNM, more lymph nodes were involved in metastases and the metastatic tumors were larger in lateral LNM. Extranodal extension (ENE) was more commonly observed in lateral LNM (p<0.001) and was associated with tumor size >10 mm, multifocality, PNI, ETE, and the absence of lymphocytic thyroiditis (p<0.05).
Conclusions
Younger age, male sex, tumor size >10 mm, LVI, and ETE were risk factors for central LNM, while male sex, tumor size >10 mm, and LVI were risk factors for lateral LNM. ENE was more commonly observed in lateral LNM, and tumor size >10 mm, multifocal tumors, PNI, ETE, and tumors unrelated to lymphocytic thyroiditis were risk factors for ENE.

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Alterations in the amino acid profile in patients with papillary thyroid carcinoma with and without Hashimoto’s thyroiditis
Andrzej Hellmann, Jacek Turyn, Agata Zwara, Justyna Korczynska, Aleksandra Taciak, Adriana Mika
Frontiers in Endocrinology.2023;[Epub] CrossRef

Expression of vascular endothelial growth factor is a clinically useful predictor for aggressive basal cell carcinoma: Jong Soon Choi, Dong Chan Lee, Hee Kyung Chang; Kosin Med J. 2018;33(1):75-84. Published online January 21, 2018; DOI: https://doi.org/10.7180/kmj.2018.33.1.75

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Abstract PDF PubReader: Objectives
Basal cell carcinoma (BCC) tumors are locally invasive but rarely metastatic. However, aggressive metastatic variants are being increasingly reported in elderly people. Here we investigated the clinical utility of vascular endothelial growth factor (VEGF) as a predictive biomarker for aggressive BCC variants.
Methods
Thirty-five pathologically confirmed cases of BCC that underwent surgical removal in the Plastic Surgery Department between January 1, 2011 and December 31, 2012 were studied. VEGF expression was analyzed in formalin-fixed paraffin-embedded tumor tissue by immunohistochemical staining. Positive staining was defined as more than 10% of the tumor cells showing immunoreactivity. The associations of VEGF expression with various clinicopathologic parameters were analyzed.
Results
The face was the most prevalent site (28/35), with 15 cases from the nose, 6 cases from the eyelid, and 5 cases from the cheek. The patients were aged between 41 and 86 years, with a mean age of 69.26 ± 173.903 years. The mean BCC size was 1.34 ± 3.853 cm, with a range of 0.3 cm to 12.0 cm. The mean tumor invasion depth from the basement epidermal membrane was 0.17 ± 0.035 cm, with a range of 0.03 cm to 1.10 cm. A mean of 5.66 ± 20.938 intraoperative frozen section slides were examined. VEGF was not expressed in 14 of the 35 patients (40.0%), whereas 42.9% of the patients had low expression and 17.1% of the patients had high expression. VEGF expression was significantly associated with age (P = 0.022), size (P = 0.030), site (P = 0.013), tumor invasion depth (P = 0.019), and number of intraoperatively frozen sections (P = 0.003).
Conclusions
These results suggest that VEGF expression as assessed by immunohistochemistry can predict aggressive or poor prognosis in BCC.

Risk Factors of Lymph Node Metastasis in Colon Cancers: Dong Min Hong, Bong Kwon Chun, Hee Kyung Chang; Kosin Med J. 2009;24(2):130-134. Published online December 31, 2009

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The Gene Profiling of Colon Cancer-Associated Genes From Colon Cancer Tissue: Min Jung Jung, Hee Kyung Chang; Kosin Med J. 2008;23(4):12-19. Published online December 31, 2008

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The Expression of Survivin mRNA in Patients with Colorectal Carcinomas to The Liver Metastasis: Jong Soon Choi, Hee Kyung Chang; Kosin Med J. 2008;23(1):26-30. Published online March 31, 2008

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Microsatellite Instability and Pathologic Characteristics of Sporadic Intestinal Type Adenocarcinoma of Stomach: Chang Hee Cho, Yu Chan Hong, Ji Hyun Ahn, Kyung Hyun Choi, Sang Ho Lee, Young Myeong Shin, Ki Young Yoon, Min Jung Jung, Hee Kyung Chang; Kosin Med J. 2007;22(2):18-23. Published online December 31, 2007

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The Incidence and Pathologic Analysis for Patients with Large Gastric Tumors over 8cm: So Yoon Choi, Young Jin Lee, Ji Hyun Ahn, Min Jung Jung, Hee Kyung Chang; Kosin Med J. 2007;22(1):43-48. Published online June 30, 2007

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Huge Agrressive Angiomyxoma of the Labia Majora: Chul Min Lee, Yeon Myung Shin, Hee Kyung Chang; Kosin Med J. 2007;22(1):253-255. Published online June 30, 2007

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Male Breast Carcinoma Report of Three Cases and Literature Review: Chung Han Lee, Sung Do Lee, Jae Kwan Seo, Young Hoon Park, Hee Kyung Chang, Bang Hur, Man Ha Huh; The Journal of Kosin Medical College. 1988;4(1):123-128.

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Clear Cell Carcinoma of Thyroid Gland Ensuing Renal Cell Carcinoma after 15 Years Duration - A case report - - Histochemical and Immunohistochemical Studies -: Hee Kyung Chang, Hae Sook Kim, Bang Hur, Man Ha Huh; The Journal of Kosin Medical College. 1988;4(1):129-135.

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Granular Cell Ameloblastoma of Jaw - A Case Report -: Bang Hur, Hae Sook Kim, Hee Kyung Chang, Man Ha Huh; The Journal of Kosin Medical College. 1988;4(1):137-141.

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Congenital Cystic Adenomatoid Malformation of the Lung with Multiple Lymphangiectasis in various Organs: Hee Kyung Chang, Man Ha Huh; The Journal of Kosin Medical College. 1989;5(1):173-181.

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Thyroid Lesions among Koreans - A statistical study on cases -: Bong Kwon Chun, Hee Kyung Chang, Bang Hur, Man Ha Huh; The Journal of Kosin Medical College. 1989;5(2):37-54.

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Proliferating Trichilemmal Tumor -Report of two cases-: Jae Hee Suh, Hee Kyung Chang, Man-Ha Hur; The Journal of Kosin Medical College. 1990;6(2):185-195.

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A Case of Sarcoidosis: Kwang Kim, Seong Jin Jeon, Kee Suck Suh, Sang Tae Kim, Man Hong Jeong, Soon Ae Oak, Hee Kyung Chang, Man Ha Huh; The Journal of Kosin Medical College. 1991;7(1):75-86.

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